Short‐term heritable variation overwhelms 200 generations of mutational variance for metabolic traits inCaenorhabditis elegans

Spontaneous mutational variation for body size in Caenorhabditis elegans.

We measured the impact of new mutations on genetic variation for body size in two independent sets of C. elegans spontaneous mutation-accumulation (MA) lines, derived from the N2 strain, that had been maintained by selfing for 60 or 152 generations. The two sets of lines gave broadly consistent results. The change of among-line genetic variation between cryopreserved controls and the MA lines i...

Invariance (?) of Mutational Parameters for Relative Fitness Over 400 Generations of Mutation Accumulation in Caenorhabditis elegans

Evidence is accumulating that individuals in poor physiologic condition may accumulate mutational damage faster than individuals in good condition. If poor condition results from pre-existing deleterious mutations, the result is "fitness-dependent mutation rate," which has interesting theoretical implications. Here we report a study in which 10 mutation accumulation (MA) lines of the nematode C...

Genetic Screening for Heritable Traits

Abg 401 Heritable and Non-heritable Traits

Changes in variance explained by top SNP windows over generations for three traits in broiler chicken

The purpose of this study was to determine if the set of genomic regions inferred as accounting for the majority of genetic variation in quantitative traits remain stable over multiple generations of selection. The data set contained phenotypes for five generations of broiler chicken for body weight, breast meat, and leg score. The population consisted of 294,632 animals over five generations a...